Potential lipid-based strategies of amphotericin B designed for oral administration in clinical application

Autor:	Xiaoming Zhong, Jianqiong Yang, Hongyan Liu, Zhiwen Yang, Ping Luo
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	AmB oral formulation clinical application cochleates encochleates emulsions Therapeutics. Pharmacology RM1-950
Zdroj:	Drug Delivery, Vol 30, Iss 1 (2023)
Druh dokumentu:	article
ISSN:	10717544 1521-0464 1071-7544
DOI:	10.1080/10717544.2022.2161671
Popis:	AbstractAmphotericin B (AmB) is regarded as a first-line therapy against life-threatening invasive fungal infections. Due to its poor oral bioavailability, AmB is restricted to intravenous administration in clinical practice. As science continues to move forward, two lipid-based formulations are successfully developed for oral AmB administration, currently undergoing phase I clinical trials. Encouragingly, lipid-AmB conjugates with emulsions also exhibit a better bioavailability, which may be another strategy to design oral AmB formulation in clinical practice. Thus, this review mainly focused on the two lipid-based formulations in clinical trials, and discussed the potential perspectives of AmB-lipid conjugation-loaded nanocochleates and emulsions.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ffcbbbb50a594155b7731a1f3df533eb Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.