The causal effects of lifestyle, circulating, pigment, and metabolic factors on early age-related macular degeneration: a comprehensive Mendelian randomization study

Autor:	Gang Shen, Yaqiong Chen, Jiahao Chen, Lingling Wang, Huanhuan Cheng, Bo Hu, Jiao Gong
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Early age-related macular degeneration Mendelian randomization Lifestyle factors Serum lipids Skin and hair color Metabolic factors Medicine
Zdroj:	Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Druh dokumentu:	article
ISSN:	1479-5876
DOI:	10.1186/s12967-024-05773-9
Popis:	Abstract Purpose Early detection of lifestyle factors, skin and hair color, circulating parameters, and metabolic comorbidities is crucial for personalized prevention and treatment of early age-related macular degeneration (AMD). This study aimed to assess the relationships between genetically predicted comprehensive risk factors and early AMD. Methods and results Publicly available genome-wide association study (GWAS) data were utilized to identify genetic variants significantly associated with each trait. We applied a Bonferroni-corrected significance level of P
Databáze:	Directory of Open Access Journals
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