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Summary: Background: Although the beneficial role of ginger consumption on peptic ulcer disease (PUD) has been shown in experimental studies, there is no clinical trial on patients with PUD. Methods: The current study was performed as a randomized, double blind, placebo-controlled, clinical trial on patients with PUD. Patients were randomized to take either ginger (2000mg/day) or placebo as a supplement after the standard treatment for 6 weeks. At the beginning and the week 8, all participants underwent endoscopic exam, and gastric ulcers were evaluated and biopsied for pathologic assessment. Serum high-sensitive C-reactive protein (hs-CRP), IL-8, and total anti-oxidant capacity (TAC) were measured at the baseline, and the end of the study. Results: There was no significant difference in the number of ulcers at baseline and ending point of the study in the control group (P-value=0.772). Meanwhile, the number of ulcers were significantly lower in the intervention group after 6 weeks of ginger supplementation compared to the baseline (P-value=0.01). Moreover, higher reduction in mean dyspepsia scores was found in the intervention group compared to the control group (P=0.04). As another finding, the mean TAC increase in the intervention group (1.12±0.44 U/ml) was significantly higher than the control group (0.09±0.16 U/ml) (P |
