Seven challenges in modeling pathogen dynamics within-host and across scales
| Autor: | Julia R. Gog, Lorenzo Pellis, James L.N. Wood, Angela R. McLean, Nimalan Arinaminpathy, James O. Lloyd-Smith |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Epidemics, Vol 10, Iss C, Pp 45-48 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1755-4365 1878-0067 |
| DOI: | 10.1016/j.epidem.2014.09.009 |
| Popis: | The population dynamics of infectious disease is a mature field in terms of theory and to some extent, application. However for microparasites, the theory and application of models of the dynamics within a single infected host is still an open field. Further, connecting across the scales – from cellular to host level, to population level – has potential to vastly improve our understanding of pathogen dynamics and evolution. Here, we highlight seven challenges in the following areas: transmission bottlenecks, heterogeneity within host, dynamic fitness landscapes within hosts, making use of next-generation sequencing data, capturing superinfection and when and how to model more than two scales. |
| Databáze: | Directory of Open Access Journals |
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