Interobserver Agreement for Endometrial Cancer Characteristics Evaluated on Biopsy Material

Autor: S. Nofech-Mozes, N. Ismiil, V. Dubé, R. S. Saad, Z. Ghorab, A. Grin, I. Ackerman, M. A. Khalifa
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Obstetrics and Gynecology International, Vol 2012 (2012)
Druh dokumentu: article
ISSN: 1687-9589
1687-9597
DOI: 10.1155/2012/414086
Popis: A shift toward a disease-based therapy designed according to patterns of failure and likelihood of nodal involvement predicted by pathologic determinants has recently led to considering a selective approach to lymphadenectomy for endometrial cancer. Therefore, it became critical to examine reproducibility of diagnosing the key determinants of risk, on preoperative endometrial tissue samples as well as the concordance between preoperative and postresection specimens. Six gynaecologic pathologists assessed 105 consecutive endometrial biopsies originally reported as positive for endometrial cancer for cell type (endometrioid versus nonendometrioid), tumor grade (FIGO 3-tiered and 2-tiered), nuclear grade, and risk category (low risk defined as endometrioid histology, grade 1 + 2 and nuclear grade
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