Autor: |
Rafael H. Isaac, Deyanira Gonzalez-Devia, Carlos O. Mendivil, Edgardo Chapman |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
Frontiers in Allergy, Vol 4 (2023) |
Druh dokumentu: |
article |
ISSN: |
2673-6101 |
DOI: |
10.3389/falgy.2023.1201807 |
Popis: |
Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive metabolic disorder that causes extremely elevated plasma triglyceride levels, with limited therapeutic options. Volanesorsen is an antisense oligonucleotide approved for its treatment. A 24-year-old woman with genetically diagnosed FCS secondary to a pathogenic variant in APOA5 and a history of recurrent hypertriglyceridemia-induced pancreatitis episodes was being treated with volanesorsen, 285 mg every 2 weeks. Treatment with volanesorsen achieved normalization of triglycerides to |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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