Phaeophytins from Thyrsacanthus ramosissimus Moric. with inhibitory activity on human dna topoisomerase II-α
| Autor: | Analúcia Guedes Silveira Cabral, Fábio Henrique Tenório-Souza, Marcelo Dantas Moura, Sabrina Gondim Ribeiro Mota, Antônio Cláudio da Silva Lins, Celidarque da Silva Dias, José Maria Barbosa-Filho, Ana Maria Giulietti, Tania Maria Sarmento da Silva, Creusioni Figueredo dos Santos |
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| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Química Nova, Vol 35, Iss 11, Pp 2222-2225 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1678-7064 0100-4042 |
| DOI: | 10.1590/S0100-40422012001100023 |
| Popis: | Our study reports the extraction and isolation of a new phaeophytin derivative 15¹-hydroxy-(15¹-S)-porphyrinolactone, designated anamariaine (1) herein, isolated from the chloroform fraction of aerial parts of Thyrsacanthus ramosissimus Moric. along with the known 15¹-ethoxy-(15¹-S)-porphyrinolactone (2). These compounds were identified by usual spectroscopic methods. Both compounds were subjected to in vitro (inhibitory activity) tests by means of supercoiled DNA relaxation techniques and were shown to display inhibitory activity against human DNA topoisomerase II-α at 50 µM. Interconversion of these two pigments under the mild conditions of the isolation techniques should be highly unlikely but cannot be entirely ruled out. |
| Databáze: | Directory of Open Access Journals |
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