Response to hepatitis B vaccination among HIV-infected adults in Vietnam

Autor: Todd M. Pollack, Le Thi Thu Trang, Long Ngo, Do Duy Cuong, Pham Thanh Thuy, Donn J. Colby
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Journal of Virus Eradication, Vol 2, Iss 2, Pp 102-106 (2016)
Druh dokumentu: article
ISSN: 2055-6640
DOI: 10.1016/S2055-6640(20)30471-4
Popis: Objectives: We sought to determine the rate of response to hepatitis B (HBV) vaccination among HIV-infected adults in Vietnam. Methods: We retrospectively abstracted data from a cohort of HIV-infected adults who had received HBV vaccine at an HIV clinic in Hanoi. We examined demographic, clinical and laboratory factors for associations with development of a protective antibody (Ab) response following vaccination (defined as ‘responders’ with anti-HBs >10 IU/L). Results: Out of 302 HIV-infected patients who completed the vaccine series and follow-up serology testing, 189 (62.6%) had a positive protective Ab response. Female patients had a higher response rate compared to male patients (71.4% vs 56.8%, P=0.01). Among responders, mean CD4 T cell count was 309 cells/μL as compared to 204 cells/μL in non-responders (P
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