Exposure to diisononyl phthalate deteriorates the quality of porcine oocytes by inducing the apoptosis

Autor: Rui Wang, Jingyue Chen, Zhaokang Cui, Yu Li, Qian Gao, Yilong Miao, Huili Wang, Bo Xiong
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Ecotoxicology and Environmental Safety, Vol 254, Iss , Pp 114768- (2023)
Druh dokumentu: article
ISSN: 0147-6513
DOI: 10.1016/j.ecoenv.2023.114768
Popis: Diisononyl phthalate (DINP), a mixture of chemical compounds composed of diverse isononyl esters of phthalic acid, is commonly applied as a plasticizer to substitute for di (2-ethylhexyl) phthalate (DEHP). It has been demonstrated that DINP exposure impairs the functions of kidney and liver in animals. However, the effects and potential mechanisms of DINP exposure on the female reproduction, especially the oocyte quality are still poorly understood. Here, we discovered that DINP exposure weakened the porcine oocyte meiotic competency (78.9% vs 53.6%, P
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