Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations.

Autor: Charlotte Andersson, Maria Lukács Krogager, Regitze Kuhr Skals, Emil Vincent Rosenbaum Appel, Christian Theil Have, Niels Grarup, Oluf Pedersen, Jørgen L Jeppesen, Ole Dyg Pedersen, Helena Dominguez, Ulrik Dixen, Thomas Engstrøm, Niels Tønder, Dan M Roden, Steen Stender, Gunnar H Gislason, Henrik Enghusen-Poulsen, Torben Hansen, Lars Køber, Christian Torp-Pedersen, Peter E Weeke
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: PLoS ONE, Vol 14, Iss 2, p e0211690 (2019)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0211690
Popis: BACKGROUND:The relation between burden of risk factors, familial coronary artery disease (CAD), and known genetic variants underlying CAD and low-density lipoprotein cholesterol (LDL-C) levels is not well-explored in clinical samples. We aimed to investigate the association of these measures with age at onset of CAD requiring revascularizations in a clinical sample of patients undergoing first-time coronary angiography. METHODS:1599 individuals (mean age 64 years [min-max 29-96 years], 28% women) were genotyped (from blood drawn as part of usual clinical care) in the Copenhagen area (2010-2014). The burden of common genetic variants was measured as aggregated genetic risk scores (GRS) of single nucleotide polymorphisms (SNPs) discovered in genome-wide association studies. RESULTS:Self-reported familial CAD (prevalent in 41% of the sample) was associated with -3.2 years (95% confidence interval -4.5, -2.2, p
Databáze: Directory of Open Access Journals
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