Oxidized cholesterol exacerbates toll-like receptor 4 expression and activity in the hearts of rats with myocardial infarction

Autor:	Arash Khorrami, Mojtaba Ziaee, Maryam Rameshrad, Ailar Nakhlband, Nasrin Maleki-Dizaji, Alireza Garjani
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	oxidized cholesterol toll-like receptor 4 inflammation myocardial infarction cytokine rats Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Journal of Cardiovascular and Thoracic Research, Vol 12, Iss 1, Pp 43-50 (2020)
Druh dokumentu:	article
ISSN:	2008-5117 2008-6830
DOI:	10.34172/jcvtr.2020.07
Popis:	Introduction: The present study examined the effects of high cholesterol and high oxidized-cholesterol diets on the myocardial expression of TLR4 and pro-inflammatory cytokine in rats. Methods: Male Wistar rats were allocated into 6 groups and fed with a normal diet, cholesterol, and oxidized-cholesterol rich diets with or without isoproterenol-induced myocardial infarction. TLR4 and MyD 88 expression and levels tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were measured in the heart and serum. Results: Oxidized cholesterol-fed animals had higher serum levels of oxidized low-density lipoprotein (LDL) (263 ± 13 ng/dL) than the cholesterol-fed animals (98 ± 8 ng/dL; P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ff6716963b464cc6ab0b7e65fb32173b Zobrazit plný text záznamu View record in DOAJ