Identification of novel somatic fusions of ERG‐VEGFA, TMPRSS2‐ERG, and VEGFA‐TMPRSS2 in prostate cancer treated with anlotinib and androgen deprivation therapy: A case report

Autor: Qiuli Liu, Shuo Wang, Ze Wang, Peng Tang, Dianzheng Zhang, Weihua Lan, Jun Jiang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Cancer Innovation, Vol 1, Iss 1, Pp 114-118 (2022)
Druh dokumentu: article
ISSN: 2770-9183
DOI: 10.1002/cai2.11
Popis: Abstract The TMPRSS2‐ERG fusion gene has frequently been found in prostate cancer and is associated with malignancy. Identifying novel fusions will help to stratify patients and establish patient‐tailored therapies. A 78‐year‐old man presented to our hospital with severe symptoms of urinary urgency and frequency for 2 years, as well as severe bone pain for 1 year. He was diagnosed with metastatic prostate cancer with a Gleason score of 5 + 5. Three gene fusions, ERG_VEGFA, TMPRSS2_ERG, and VEGFA_TMPRSS2, were identified in the patient's prostate cancer tissue. Notably, administration of the tyrosine kinase inhibitor, anlotinib, in combination with a gonadotropin‐releasing hormone agonist (GnRHa) and abiraterone, reduced the patient's bone pain and also stabilized his prostate cancer for more than 2 years. This is the first report of somatic fusions among the VEGFA, ERG, and TMPRSS2 genes in cancer tissues from a patient with prostate cancer who responded well to antiangiogenic treatment combined with a GnRHa and abiraterone.
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