Rosuvastatin Counteracts Vessel Arterialisation and Sinusoid Capillarisation, Reduces Tumour Growth, and Prolongs Survival in Murine Hepatocellular Carcinoma

Autor:	Annemilaï Tijeras-Raballand, Patricia Hainaud-Hakim, Jean-Olivier Contreres, Caroline Gest, Carole Le Henaff, Bernard I Levy, Marc Pocard, Claudine Soria, Evelyne Dupuy
Jazyk:	angličtina
Rok vydání:	2010
Předmět:	Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	Gastroenterology Research and Practice, Vol 2010 (2010)
Druh dokumentu:	article
ISSN:	1687-6121 1687-630X
DOI:	10.1155/2010/640797
Popis:	Background and Aims. An arterial blood supply and phenotypic changes of the sinusoids characterise the liver vasculature in human hepatocellular carcinoma (HCC). We investigated the effects of rosuvastatin on liver vessel anomalies, tumour growth and survival in HCC. Methods. We treated transgenic mice developing HCC, characterized by vessel anomalies similar to those of human HCC, with rosuvastatin. Results. In the rosuvastatin group, the survival time was longer (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/cff483bf9daf4c1cb24376d69f98916d Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF