| Autor: |
Ana B Fagundo, Rafael de la Torre, Susana Jiménez-Murcia, Zaida Agüera, Antoni Pastor, Felipe F Casanueva, Roser Granero, Rosa Baños, Cristina Botella, Amparo Del Pino-Gutierrez, Jose M Fernández-Real, Jose C Fernández-García, Gema Frühbeck, Javier Gómez-Ambrosi, José M Menchón, Inés Moragrega, Roser Rodríguez, Salomé Tárrega, Francisco J Tinahones, Fernando Fernández-Aranda |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 8, Iss 6, p e66387 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0066387 |
| Popis: |
Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = -.37; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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