| Autor: |
Dhilli Rao Gorja, K. Shiva Kumar, K. Mukkanti, Manojit Pal |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Beilstein Journal of Organic Chemistry, Vol 7, Iss 1, Pp 338-345 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1860-5397 |
| DOI: |
10.3762/bjoc.7.44 |
| Popis: |
The Pd/C–CuI–PPh3 catalytic system facilitated C–C bond formation between 4-chlorothieno[2,3-d]pyrimidines and terminal alkynes in methanol with high selectivity without generating any significant side products arising from C–O bond formation between the chloro compounds and methanol. A variety of novel 4-alkynylthieno[2,3- d]pyrimidines were prepared via alkynylation of 4-chlorothieno[2,3-d]pyrimidines in good to excellent yields. Some of the compounds synthesized were tested for cytotoxic activity in vitro. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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