Characterization of a blaCTX-M-3, blaKPC-2 and blaTEM-1B co-producing IncN plasmid in Escherichia coli of chicken origin

Autor: Wen-jing WANG, Yi-fu WANG, Ya-jie JIN, Wu-qiang SONG, Jia-meng LIN, Yan ZHANG, Xin-ru TONG, Jian TU, Rui-chao LI, Tao LI
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Integrative Agriculture, Vol 22, Iss 1, Pp 320-324 (2023)
Druh dokumentu: article
ISSN: 2095-3119
DOI: 10.1016/j.jia.2022.08.075
Popis: An extensively drug-resistant (XDR) Escherichia coli strain 258E was isolated from an anal swab sample of a chicken farm of Anhui Province in China. Genomic analyses indicated that the strain 258E harbors an incompatibility group N (IncN) plasmid pEC258-3, which co-produces blaCTX-M-3, blaKPC-2, blaTEM-1B, qnrS1, aac(6´)-Ib-cr, dfrA14, arr-3, and aac(6´)-Ib3. Multiple genome arrangement analyses indicated that pEC258-3 is highly homologous with pCRKP-1-KPC discovered in Klebsiella pneumoniae from a patient. Furthermore, conjugation experiments proved that plasmid pEC258-3 can be transferred horizontally and may pose a significant potential threat in animals, community and hospital settings.
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