Association between biomarkers of zinc and copper status and heart failure: a meta‐analysis

Autor: Ruixin Liu, Jiali Yao, Kexian Chen, Wei Peng
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: ESC Heart Failure, Vol 11, Iss 5, Pp 2546-2556 (2024)
Druh dokumentu: article
ISSN: 2055-5822
DOI: 10.1002/ehf2.14837
Popis: Abstract Aims Previous studies have investigated the relationship between heart failure (HF) and levels of zinc and copper, but conflicting results have been reported. This meta‐analysis aims to clarify the role of zinc and copper in HF progression by examining the associations between HF and concentrations of these minerals. Methods and results We utilized STATA 12.0 software to calculate the standard mean difference (SMD) and 95% confidence interval (CI) for serum zinc and copper levels in patients with HF compared with healthy controls (HCs). The meta‐analysis indicated a lower serum zinc level in patients with HF compared with HCs, using a random effects model (SMD = −0.77; 95% CI: −1.01, −0.54; I2 = 61.9%, the P‐value for Q test = 0.002). Additionally, the meta‐analysis showed an increased serum copper level in patients with HF compared with HCs, using a random effects model (SMD = 0.66; 95% CI: 0.09, 1.23; I2 = 93.8%, the P‐value for Q test
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