An inner activation gate controls TMEM16F phospholipid scrambling

Autor: Trieu Le, Zhiguang Jia, Son C. Le, Yang Zhang, Jianhan Chen, Huanghe Yang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-09778-7
Popis: TMEM16F is an enigmatic Ca2 + -activated phospholipid scramblase (CaPLSase) that passively transports phospholipids. Here authors identify an inner activation gate and its disruption profoundly alters TMEM16F phospholipid permeation.
Databáze: Directory of Open Access Journals