Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice

Autor:	Miriam Zamorano, Jenolyn F. Alexander, Desiree Catania, Shruti Dharmaraj, Annemieke Kavelaars, Cobi J. Heijnen
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	chemobrain accelerated aging cellular therapy regenerative medicine cancer treatment chemotherapy Immunologic diseases. Allergy RC581-607 Geriatrics RC952-954.6
Zdroj:	Immunity & Ageing, Vol 20, Iss 1, Pp 1-18 (2023)
Druh dokumentu:	article
ISSN:	1742-4933
DOI:	10.1186/s12979-023-00328-w
Popis:	Highlights • Cisplatin accelerates formation of tau deposits in entorhinal cortex and hippocampus of older female and male mice. • Nasal administration of MSC after cisplatin prevents formation of tau deposits in the brain. • Tau deposits are associated with astrocyte activation but not with activation of microglia. • Most of the tau deposits in cisplatin-treated mice develop in neurons. • Nasal administration of MSC reverses cognitive deficits in older mice treated with cisplatin.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/fefcbd1c7c8f45ca871d07b0cc6694ed Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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