| Autor: |
Chloé Melchior, Emilien Loeuillard, Rachel Marion-Letellier, Lionel Nicol, Paul Mulder, Charlène Guerin, Christine Bôle-Feysot, Moutaz Aziz, Pierre Déchelotte, Pierre Vera, Guillaume Savoye, Céline Savoye-Collet |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 9, Iss 7, p e100921 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0100921 |
| Popis: |
BACKGROUND: Magnetic resonance colonography (MRC) has been developed to assess inflammatory bowel diseases. We aimed to assess the feasibility of MRC in rats with TNBS-induced chronic colitis and to confront imaging results with fibrosis and stenosing features of the model. MATERIALS AND METHODS: Chronic colitis was induced in 12 rats by weekly intra-rectal injection of increasing doses of TNBS for 6 weeks, while 8 control rats received the vehicle. At week 7, MRC was performed. Fibrosis scores were assessed and fibrosis mediators measured. RESULTS: Chronic colitis was associated with significant body weight loss (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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