Uric Acid Levels and All-Cause Mortality in Peritoneal Dialysis Patients
| Autor: | Sheng Feng, Linseng Jiang, Yongbing Shi, Huaying Shen, Xiaosong Shi, Donghua Jin, Ying Zeng, Zhi Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Kidney & Blood Pressure Research, Vol 37, Iss 2-3, Pp 181-189 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1420-4096 1423-0143 |
| DOI: | 10.1159/000350143 |
| Popis: | Background: Epidemiological studies have shown that hyperuricemia is associated with all-cause and cardiovascular mortality in chronic kidney disease (CKD) and hemodialysis patients. Our study investigated the influence of serum uric acid (UA) levels on survival in peritoneal dialysis (PD) patients. Methods: This was a retrospective study involving 156 subjects who had undergone PD. The patient demographics, etiology of ESRD, comorbid conditions and other laboratory parameters were collected. The subjects were divided into three groups according to their serum UA concentrations (group 1, the lowest quartile; group 2, the middle quartiles; group 3, the highest quartile). The risk of death was calculated using a multivariate Cox regression model. Results: There were 41 deaths during a follow-up period of 31.3±17.5 months. Compared with group 2, which had a mortality rate of 5.7 per 1000 person-months, the mortality rates were higher in group 1 (14.3 per 1000 person-months, p0.05) for group 1 and 2.96 (95% CI 1.29-6.80, p=0.01) for group 3. Conclusions: In PD patients, a higher serum UA level is related to increased mortality and is an independent risk factor for all-cause mortality. Uric acid levels and all-cause mortality in peritoneal dialysis patients. |
| Databáze: | Directory of Open Access Journals |
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