Categorization of adverse drug reactions in electronic health records

Autor: Caroline Foreman, William B. Smith, Gillian E. Caughey, Sepehr Shakib
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
Druh dokumentu: article
ISSN: 2052-1707
DOI: 10.1002/prp2.550
Popis: Abstract The purpose of this study was to evaluate the quality of adverse drug reaction (ADR) documentation in a state‐wide electronic health record (EHR), and to assess the impact of the interface design on documentation accuracy and ability to provide decision support. Data were extracted from 43 011 unique records in a state‐wide electronic health record in South Australia, Australia. Information obtained included ADR coding as allergy or intolerance, allergen name, reaction, and occupation of those entering data. Categorization into drug allergy or intolerance was assessed for accuracy. Reactions were entered predominantly by nurses (60.1%), also by doctors (31.0%) and pharmacists (6.1%). Of 27 314 reactions, 86.5% were coded as allergy and 13.5% as intolerance. The majority (78.2%) described reactions to drugs (as opposed to food, environmental or contact allergens), predominantly chosen from the drug database (96.4%). Many entries used free text for the reaction description (27.4%). Terms found in the predefined list under the allergy heading were more likely to be categorized as allergy, even when the mechanism was pharmacological intolerance. Only 45.1% (n = 1671/3705) of reactions consistent with intolerance (eg, “nausea,” “diarrhea”) were correctly categorized as such, although categorization by pharmacists was more accurate (P
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