The prognostic value and immune microenvironment association of AR in HER2+ nonmetastatic breast cancer

Autor: Danyang Zhou, Mei Li, Mohamed Hussein Yasin, Qianyi Lu, Jia Fu, Kuikui Jiang, Ruoxi Hong, Shusen Wang, Fei Xu
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: npj Breast Cancer, Vol 9, Iss 1, Pp 1-10 (2023)
Druh dokumentu: article
ISSN: 2374-4677
DOI: 10.1038/s41523-023-00527-0
Popis: Abstract This study aimed to investigate the prognostic value of AR in HER2+ nonmetastatic breast invasive ductal carcinoma (IDC) and its relationship with the immune microenvironment. HER2+ nonmetastatic breast IDC patients diagnosed by pathology who underwent surgery at Sun Yat-sen University Cancer Center from 2016 to 2017 were included. AR+ and AR− breast IDC samples were matched 1:1 in age, T stage, and N stage for immune infiltration analysis. A total of 554 patients with HER2+ nonmetastatic breast cancer were included in this retrospective study, regardless of HR status. The cut-off value for AR was set at 10%. ER+ (p
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