Effectiveness and safety of follitropin alfa (Ovaleap®) for ovarian stimulation using a GnRH antagonist protocol in real-world clinical practice: a multicenter, prospective, open, non-interventional assisted reproductive technology study

Autor: Peter Sydow, Norbert Gmeinwieser, Katrin Pribbernow, Christoph Keck, Inka Wiegratz
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Reproductive Biology and Endocrinology, Vol 18, Iss 1, Pp 1-9 (2020)
Druh dokumentu: article
ISSN: 1477-7827
DOI: 10.1186/s12958-020-00610-2
Popis: Abstract Background The use of recombinant human follicle-stimulating hormone (r-hFSH) in ovarian stimulation protocols for infertility treatment in assisted reproductive technology (ART) clinical practice is well established. More recent advancements include the availability of biosimilar r-hFSH products, which expand the choices available to healthcare practitioners and patients. Better understanding of how such a product contributes to routine clinical practice is valuable to help prescribers make informed treatment choices. The objective of this study was to examine the effectiveness and safety of ovarian stimulation (OS) with follitropin alfa (Ovaleap®) for routine IVF or intracytoplasmic sperm injection treatment in gonadotropin-releasing hormone (GnRH) antagonist cycles in real-world ART clinical practice. Methods This non-interventional, multicenter, prospective study was initiated in 34 specialized reproductive medicine centers in Germany. Eligible women were 18–40 years old with a body mass index
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