| Autor: |
Mauricio Pinto, Thibaud Mathis, Pascale Massin, Jad Akesbi, Théo Lereuil, Nicolas Voirin, Frédéric Matonti, Franck Fajnkuchen, John Conrath, Solange Milazzo, Jean-François Korobelnik, Stéphanie Baillif, Philippe Denis, Catherine Creuzot-Garcher, Mayer Srour, Bénédicte Dupas, Aditya Sudhalkar, Alper Bilgic, Ramin Tadayoni, Eric H Souied, Corinne Dot, Laurent Kodjikian |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Pharmaceutics, Vol 13, Iss 2, p 194 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1999-4923 |
| DOI: |
10.3390/pharmaceutics13020194 |
| Popis: |
The purpose of this study is to evaluate the visual acuity (VA) gain profiles between patients with drug-naive diabetic macular edema (DME) treated by dexamethasone implant (DEX-implant) and assess the baseline anatomical and functional factors that could influence the response to the treatment in real-life conditions. A retrospective, multi-center observational study included 129 eyes with drug-naive DME treated by DEX-implant. The Median follow-up was 13 months. Two groups of VA gain trajectories were identified—Group A, with 71% (n = 96) of patients whose average VA gain was less than five letters and Group B, with 29% (n = 33) of patients with an average gain of 20 letters. The probability of belonging to Group B was significantly higher in patients with baseline VA < 37 letters (p = 0.001). Ellipsoid zone alterations (EZAs) or disorganization of retinal inner layers (DRILs) were associated with a lower final VA (53.0 letters versus 66.4, p = 0.002) but without a significant difference in VA gain (4.9 letters versus 6.8, p = 0.582). Despite a low baseline VA, this subgroup of patients tends to have greater visual gain, encouraging treatment with DEX-implant in such advanced-stage disease. However, some baseline anatomic parameters, such as the presence of EZAs or DRILs, negatively influenced final vision. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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