Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment

Autor: Jefferson Luiz Gross, Marcel Adalid Tapia Vega, Guilherme Strambi Frenhi, Silvio Melo Torres, Antonio Hugo José Froes Marques Campos, Clovis Antonio Lopes Pinto, Felipe D’Almeida Costa, Fabio José Haddad
Jazyk: English<br />Portuguese
Předmět:
Zdroj: Jornal Brasileiro de Pneumologia, Vol 45, Iss 5
Druh dokumentu: article
ISSN: 1806-3756
1806-3713
DOI: 10.1590/1806-3713/e20180140
Popis: ABSTRACT Objective: To analyze determinants of prognosis in patients with bronchial carcinoid tumors treated surgically and the potential concomitance of such tumors with second primary neoplasms. Methods: This was a retrospective analysis of 51 bronchial carcinoid tumors treated surgically between 2007 and 2016. Disease-free survival (DFS) was calculated by the Kaplan-Meier method, and determinants of prognosis were evaluated. Primary neoplasms that were concomitant with the bronchial carcinoid tumors were identified by reviewing patient charts. Results: The median age was 51.2 years, 58.8% of the patients were female, and 52.9% were asymptomatic. The most common histology was typical carcinoid (in 80.4%). Five-year DFS was 89.8%. Ki-67 expression was determined in 27 patients, and five-year DFS was better among the patients in whom Ki-67 expression was ≤ 5% than among those in whom it was > 5% (100% vs. 47.6%; p = 0.01). Concomitant primary neoplasms were observed in 14 (27.4%) of the 51 cases. Among the concomitant primary neoplasms that were malignant, the most common was lung adenocarcinoma, which was observed in 3 cases. Concomitant primary neoplasms were more common in patients who were asymptomatic and in those with small tumors. Conclusions: Surgical resection is the mainstay treatment of bronchopulmonary carcinoid tumors and confers a good prognosis. Bronchial carcinoid tumors are likely to be accompanied by second primary neoplasms.
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