Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response
Autor: | Suhyeon Kim, Si-Yeon Lee, Seoyoon Bae, Jin-Kwan Lee, Kyungrim Hwang, Heounjeong Go, Chang-Woo Lee |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: | |
Zdroj: | Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1537-1549 (2020) |
Druh dokumentu: | article |
ISSN: | 1226-3613 2092-6413 |
DOI: | 10.1038/s12276-020-00489-4 |
Popis: | Psoriasis: Regulatory protein linked to chronic inflammation An immune-regulating protein that mediates chronic inflammation in the skin offers a new therapeutic target for the autoimmune disorder psoriasis. A research team from South Korea led by Chang-Woo Lee from Sungkyunkwan University School of Medicine in Suwon and Heounjeong Go from the University of Ulsan College of Medicine in Seoul have discovered that Pellino1, a protein known to modulate immune responses to pathogens, is also found in abundance in the skin lesions of people with psoriasis. Using mouse models, the researchers showed how Pellino1 induces the proliferation of certain skin cells and triggers an inflammatory state through the activation of small proteins and immune cells normally involved in defense against infection. Targeting strategy that inactivate Pellino1 could help blunt the inflammatory signaling in the skin that drives the development of psoriatic lesions. |
Databáze: | Directory of Open Access Journals |
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