The Potential of the Nose-to-Brain Delivery of PACAP for the Treatment of Neuronal Disease

Autor:	Asma Cherait, William A. Banks, David Vaudry
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	pituitary adenylate cyclase-activating polypeptide intranasal delivery route neuronal diseases neuroprotection apoptosis inflammation Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceutics, Vol 15, Iss 8, p 2032 (2023)
Druh dokumentu:	article
ISSN:	15082032 1999-4923
DOI:	10.3390/pharmaceutics15082032
Popis:	Research on the neuroprotective effect of pituitary adenylate cyclase-activating polypeptide (PACAP) and its use as a therapeutic agent has grown over the past 30 years. Both in vitro and in vivo experiments have shown that PACAP exerts a strong neuroprotective effect in many central and peripheral neuronal diseases. Various delivery routes have been employed from intravenous (IV) injections to intracerebroventricular (ICV) administration, leading either to systemic or topical delivery of the peptide. Over the last decade, a growing interest in the use of intranasal (IN) administration of PACAP and other therapeutic agents has emerged as an alternative delivery route to target the brain. The aim of this review is to summarize the findings on the neuroprotective effect of PACAP and to discuss how the IN administration of PACAP could contribute to target the effects of this pleiotropic peptide.
Databáze:	Directory of Open Access Journals
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