Evaluating spine micro-architectural texture (via TBS) discriminates major osteoporotic fractures from controls both as well as and independent of site matched BMD: the Eastern European TBS study
| Autor: | J. Vasic, T. Petranova, V. Povoroznyuk, C.G. Barbu, M. Karadzic, F. Gojkovic, J. Elez, R. Winzenrieth, D. Hans, V. Culafic Vojinovic, C. Poiana, N. Dzerovych, R. Rashkov, A. Dimic |
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| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Bolʹ, Sustavy, Pozvonočnik, Vol 4, Iss 3.15, Pp 9-19 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2224-1507 2307-1133 |
| DOI: | 10.22141/2224-1507.3.15.2014.79938 |
| Popis: | The aim of the study was to assess the clinical performance of the model combining areal bone mineral density (aBMD) at spine and microarchitecural texture (TBS) for the detection of the osteoporotic fracture. The Eastern European Study is a multicenter study (Serbia, Bulgaria, Romania and Ukraine) evaluating the role of TBS in routine clinical practice as a complement to aBMD. All scans were acquired on Hologic Discovery and GE Prodigy densitometers in a routine clinical manner. The additional clinical values of aBMD and TBS were analyzed using a two steps classification tree approach (aBMD followed by TBS tertiles) for all type of osteoporotic fracture (All-OP Fx). Sensitivity, specificity and accuracy of fracture detection as well as the Net Reclassification Index (NRI) were calculated. This study involves 1031 women subjects aged 45 and older recruited in east European countries. Clinical centers were cross-calibrated in terms of BMD and TBS. As expected, areal BMD (aBMD) at spine and TBS were only moderately correlated (r2 = 0.19). Prevalence rate for All-OP Fx was 26%. Subjects with fracture have significant lower TBS and aBMD than subjects without fracture (p |
| Databáze: | Directory of Open Access Journals |
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