Hepatoprotective effect of β-myrcene pretreatment against acetaminophen-induced liver injury
| Autor: | Gabriel Cardia, Francielli Silva-Comar, Carla Bonetti, Edvalkia Rocha, Mayara Zagoto, Valeria Amaral, Livia Bracht, Saulo Silva-Filho, Ciomar Bersani-Amado, Roberto Cuman |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Avicenna Journal of Phytomedicine, Vol 12, Iss 4, Pp 388-400 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2228-7930 2228-7949 |
| DOI: | 10.22038/ajp.2022.19493 |
| Popis: | Objective: In the present study, the hepatoprotective effects of β-myrcene (MYR) on acetaminophen-induced hepatotoxicity were investigated.Materials and Methods: A total of 40 Balb/c mice were randomly divided into five groups as follows: 1) Normal control group which received only carboxymethylcellulose (CMC), the vehicle used to dissolve acetaminophen (N-acetyl-p-aminophenol, APAP, paracetamol) and MYR; 2) APAP group which received a single dose of acetaminophen (250 mg/kg) orally on day 7; 3) Silymarin group which received 200 mg/kg/day of silymarin; and 4 and 5) pretreatment groups in which, mice were treated with 100 or 200 mg/kg/day of MYR. Liver and blood samples were collected to analyze serum aminotransferases, inflammatory response, oxidative stress markers, and histopathological insults.Results: Our results showed that MYR pretreatment attenuated liver damage and restored liver cells function and integrity as it decreased the leakage of serum aminotransferases (alanine and aspartate aminotransferases (ALT and AST, respectively)) into the blood (p |
| Databáze: | Directory of Open Access Journals |
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