Polarization of TH2 response is decreased during pregnancy in systemic lupus erythematosus
| Autor: | A. Tincani, D. Villalta, M. Zen, A. Ghirardello, L. Iaccarino, L. Punzi, A. Doria |
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| Jazyk: | English<br />Italian |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Reumatismo, Vol 64, Iss 5, Pp 314-320 (2012) |
| Druh dokumentu: | article |
| ISSN: | 0048-7449 2240-2683 |
| DOI: | 10.4081/reumatismo.2012.314 |
| Popis: | This study evaluated some cytokines involved in the Th1-Th2 shift during pregnancy in patients with systemic lupus erythematosus (SLE) and healthy women. Twenty-seven consecutive successful pregnancies in 26 SLE patients and 28 pregnancies in 28 matched healthy subjects, as controls, were enrolled and prospectively studied. Sera obtained at first and third trimesters of pregnancy were tested for IL-1α, IL-1β, IL-2, IL-6, IL-8, IL-10, IL-12p70, INF-γ, and TNF-α with a highly sensitive, multiplexed sandwich ELISA (SearchLight Human Inflammatory Cytokine Array). Statistics were performed by SPSS package. IL-8 serum levels were higher in the first (P |
| Databáze: | Directory of Open Access Journals |
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