Facile Synthesis of Weakly Ferromagnetic Organogadolinium Macrochelates‐Based T1‐Weighted Magnetic Resonance Imaging Contrast Agents

Autor: Yudie Lu, Zhiyu Liang, Jie Feng, Lin Huang, Shuai Guo, Peiwei Yi, Wei Xiong, Sijin Chen, Sugeun Yang, Yikai Xu, Yan Li, Xiaoyuan Chen, Zheyu Shen
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Advanced Science, Vol 10, Iss 1, Pp n/a-n/a (2023)
Druh dokumentu: article
ISSN: 2198-3844
20220510
DOI: 10.1002/advs.202205109
Popis: Abstract To surmount the major concerns of commercial small molecule Gd chelates and reported Gd‐based contrast agents (GBCAs) for magnetic resonance imaging (MRI), a new concept of organogadolinium macrochelates (OGMCs) constructed from the coordination between Gd3+ and macromolecules is proposed. A library of macromolecules were screened for Gd3+ coordination, and two candidates [i.e., poly(acrylic acid) (PAA), and poly(aspartic acid) (PASP)] succeeded in OGMC formation. Under optimized synthesis conditions, both Gd‐PAA12 and Gd‐PASP11 OGMCs are outstanding T1‐weighted CAs owing to their super high r1 values (> 50 mm−1 s−1, 3.0 T) and ultralow r2/r1 ratios (< 1.6, 3.0 T). The ferromagnetism of OGMCs is completely different from the paramagnetism of commercial and reported GBCAs. The ferromagnetism is very weak (Ms
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