| Autor: |
Julius Nückel, Elisa Planatscher, Anne Wiebe Mohr, Karolin Deichl, Hrvoje Mijočević, Martin Feuerherd, Lisa Wolff, Johanna Erber, Jochen Schneider, Michael Quante, Christoph Winter, Jürgen Ruland, Alexander Hapfelmeier, Wolfgang Hammerschmidt, Andreas Moosmann, Ulrike Protzer, Uta Behrends, Josef Mautner |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 13 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2022.889836 |
| Popis: |
Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha- but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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