CXCL13-producing PD-1hiCXCR5− helper T cells in chronic inflammation

Autor:	Hiroyuki Yoshitomi
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	tertiary lymphoid structures cxcl13 tph cells human cd4+ t cells autoimmune diseases malignant tumors Immunologic diseases. Allergy RC581-607
Zdroj:	Immunological Medicine, Vol 43, Iss 4, Pp 156-160 (2020)
Druh dokumentu:	article
ISSN:	2578-5826 25785826
DOI:	10.1080/25785826.2020.1781998
Popis:	CXCL13-producing PD-1hiCXCR5−CD4+ T cells were discovered in synovial tissues of rheumatoid arthritis (RA). Further intensive analysis of RA samples led to the proposal of PD-1hiCXCR5−CD4+ T cells as a pathogenic CD4 subset, peripheral helper T (Tph) cells. Tph cells are upregulated also in the peripheral blood of seropositive RA patient and exert B-cell helper activities. Furthermore, Tph cells are associated with other inflammatory conditions including systemic lupus erythematosus, IgG4-related diseases, type 1 diabetes, inflammatory bowel diseases, and malignant tumors. In this review, molecular feature and pathogenic and beneficial functions of Tph cells in inflammatory conditions are discussed.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/acfe7778a0a44928b5a5f6c728205e74 Zobrazit plný text záznamu View record in DOAJ