Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies

Autor: Shweta Paroha, Ravindra Dhar Dubey, Subrata Mallick
Jazyk: English<br />Spanish; Castilian<br />Portuguese
Rok vydání: 2014
Předmět:
Zdroj: Química Nova, Vol 37, Iss 1, Pp 81-84 (2014)
Druh dokumentu: article
ISSN: 1678-7064
0100-4042
DOI: 10.1590/S0100-40422014000100015
Popis: Interaction and physicochemical characterization of dispersions of naproxen in calcium carbonate after freeze-drying the wet-state equilibrated mixture have been investigated by analytical methods. The FT-IR study revealed the acid-base reaction between naproxen and calcium carbonate. The DSC study indicated physical interaction and significantly diminished crystallinity of naproxen in the formulation containing higher quantities of calcium carbonate. Furthermore, the SEM study showed the reduced particle size and loss of crystalline morphology in the same sample. Drug release increased with the increase of calcium carbonate in the formulations. Formulation of naproxen with calcium carbonate in 1:2 ratio allowed its dissolution to the greatest extent (94.96%) while other compositions, 1:0.5 and 1:1, showed 80.86% and 78.30% release, respectively.
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