Modulation of drug resistance and biofilm formation of Staphylococcus aureus isolated from the oral cavity of Tunisian children

Autor: Tarek Zmantar, Rihab Ben Slama, Kais Fdhila, Bochra Kouidhi, Amina Bakhrouf, Kamel Chaieb
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Brazilian Journal of Infectious Diseases, Vol 21, Iss 1, Pp 27-34 (2017)
Druh dokumentu: article
ISSN: 1413-8670
DOI: 10.1016/j.bjid.2016.10.009
Popis: Objectives: This study aims to investigate the antimicrobial and the anti-biofilm activities of Lactobacillus plantarum extract (LPE) against a panel of oral Staphylococcus aureus (n = 9) and S. aureus ATCC 25923. The in vitro ability of LPE to modulate bacterial resistance to tetracycline, benzalchonium chloride, and chlorhexidine were tested also. Methods: The minimum inhibitory concentrations (MICs) and the minimal bactericidal concentrations of Lactobacillus plantarum extract, tetracycline, benzalchonium chloride and clohrhexidine were determined in absence and in presence of a sub-MIC doses of LPE (1/2 MIC). In addition, the LPE potential to inhibit biofilm formation was assessed by microtiter plate and atomic force microscopy assays. Statistical analysis was performed on SPSS v. 17.0 software using Friedman test and Wilcoxon signed ranks test. These tests were used to assess inter-group difference (p
Databáze: Directory of Open Access Journals