Lentiviral vector induces high-quality memory T cells via dendritic cells transduction

Autor: Min Wen Ku, Pierre Authié, Fabien Nevo, Philippe Souque, Maryline Bourgine, Marta Romano, Pierre Charneau, Laleh Majlessi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02251-6
Popis: Ku et al. report a lentiviral (LV) vector system in which expression of vaccine antigens is driven by β2-microglobulin (β2m) promoter. Conducting comparative studies in mice and rats, they find that LV-based vaccine outperforms the ‘gold-standard’ Ad5 by inducing a polyfunctional and long-lived immune response.
Databáze: Directory of Open Access Journals
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