Genetic polymorphism of the extracellular region in surface associated interspersed 1.1 gene of Plasmodium falciparum field isolates from Thailand

Autor:	Natpasit Chaianantakul, Tippawan Sungkapong, Jirapinya Changpad, Keawalin Thongma, Sasiwimon Sim-ut, Morakot Kaewthamasorn
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Malaria Plasmodium falciparum Gene polymorphism Variable surface antigens SURFIN Surf gene Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216
Zdroj:	Malaria Journal, Vol 20, Iss 1, Pp 1-14 (2021)
Druh dokumentu:	article
ISSN:	1475-2875
DOI:	10.1186/s12936-021-03876-y
Popis:	Highlights The regions of SURFIN1.1 were identified: SURFIN1.1 is comprised of extracellular, transmembrane (TM), and intracellular regions. Nucleotide and amino acid sequences of the extracellular region of P. falciparum SURFIN1.1 from a total of 31 field isolates were obtained and analyzed for genetic polymorphism: six different haplotypes were identified. The extracellular region of the SURFIN1.1 among field isolates was conserved, especially in the cysteine-rich domain (CRD) sub-region. High polymorphism was shown in the variable region 2 (Var2), followed by N-terminal (N-ter) and variable region 1 (Var1), respectively. The findings presented herein may enable the discovery and development of a novel SURFIN-based vaccine for prevention and control of malaria.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/dfe23b4f5f3f462b9fb98e193d766cea Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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