Cost-effectiveness of twice-weekly versus once-weekly sessions of cognitive–behavioural therapy and interpersonal psychotherapy for depression at 12 months after start of treatment: randomised controlled trial

Autor: Judith E. Bosmans, Sanne J. E. Bruijniks, Mohamed El Alili, Steven D. Hollon, Frenk P. M. L. Peeters, Arnoud Arntz, Pim Cuijpers, Lotte H. J. M. Lemmens, Pieter Dingemanse, Linda Willems, Patricia van Oppen, Michael van den Boogaard, Jan Spijker, Jos W. R. Twisk, Marcus J. H. Huibers
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: BJPsych Open, Vol 9 (2023)
Druh dokumentu: article
ISSN: 2056-4724
DOI: 10.1192/bjo.2023.548
Popis: Background Cost-effective treatments are needed to reduce the burden of depression. One way to improve the cost-effectiveness of psychotherapy might be to increase session frequency, but keep the total number of sessions constant. Aim To evaluate the cost-effectiveness of twice-weekly compared with once-weekly psychotherapy sessions after 12 months, from a societal perspective. Method An economic evaluation was conducted alongside a randomised controlled trial comparing twice-weekly versus once-weekly sessions of psychotherapy (cognitive–behavioural therapy or interpersonal psychotherapy) for depression. Missing data were handled by multiple imputation. Statistical uncertainty was estimated with bootstrapping and presented with cost-effectiveness acceptability curves. Results Differences between the two groups in depressive symptoms, physical and social functioning, and quality-adjusted life-years (QALY) at 12-month follow-up were small and not statistically significant. Total societal costs in the twice-weekly session group were higher, albeit not statistically significantly so, than in the once-weekly session group (mean difference €2065, 95% CI −686 to 5146). The probability that twice-weekly sessions are cost-effective compared with once-weekly sessions was 0.40 at a ceiling ratio of €1000 per point improvement in Beck Depression Inventory-II score, 0.32 at a ceiling ratio of €50 000 per QALY gained, 0.23 at a ceiling ratio of €1000 per point improvement in physical functioning score and 0.62 at a ceiling ratio of €1000 per point improvement in social functioning score. Conclusions Based on the current results, twice-weekly sessions of psychotherapy for depression are not cost-effective over the long term compared with once-weekly sessions.
Databáze: Directory of Open Access Journals