| Autor: |
Samer Al-Dury, Johan Waern, Jesper Waldenström, Marko Alavanja, Hevar Hamah Saed, Andreas Törnell, Mohammad Arabpour, Hanna Grauers Wiktorin, Sigrun Einarsdottir, Johan Ringlander, Gisela Ringström, Kristoffer Hellstrand, Anna Martner, Martin Lagging |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
JHEP Reports, Vol 4, Iss 7, Pp 100496- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2589-5559 |
| DOI: |
10.1016/j.jhepr.2022.100496 |
| Popis: |
Background & Aims: Cirrhosis entails elevated risk of COVID-19-associated mortality. This study determined T cell-mediated and antibody reactivity against the spike 1 (S1) protein of SARS-CoV-2 among 48 patients with cirrhosis and 39 healthy controls after mRNA COVID-19 vaccination. Methods: SARS-CoV-2-specific T-cell reactivity was measured by induced level of T cell-derived interferon-γ (IFN-γ) in blood cells stimulated ex vivo with multimeric peptides spanning the N-terminal portion of S1. S1-induced IFN-γ was quantified before and after the 1st and 2nd vaccination (BNT162b2, Pfizer-BioNTech or mRNA-1273, Moderna) alongside serum IgG against the receptor-binding domain (RBD) within S1 (anti-RBD-S1 IgG). Results: T-cell reactivity against S1 was reduced in patients with cirrhosis after the 1st (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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