Time Dependence of the Effect of Right Ventricular Dysfunction on Clinical Outcomes After Myocardial Infarction: Role of Pulmonary Hypertension

Autor: Keren Shahar, Wisam Darawsha, Sergey Yalonetsky, Jonathan Lessick, Michael Kapeliovich, Robert Dragu, Diab Mutlak, Shimon Reisner, Yoram Agmon, Doron Aronson
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 7 (2016)
Druh dokumentu: article
ISSN: 2047-9980
DOI: 10.1161/JAHA.116.003606
Popis: BackgroundThe clinical importance of right ventricular (RV) function in acute myocardial infarction is well recognized, but the impact of concomitant pulmonary hypertension (PH) has not been studied. Methods and ResultsWe studied 1044 patients with acute myocardial infarction. Patients were classified into 4 groups according to the presence or absence of RV dysfunction and PH, defined as pulmonary artery systolic pressure >35 mm Hg: normal right ventricle without PH (n=509), normal right ventricle and PH (n=373), RV dysfunction without PH (n=64), and RV dysfunction and PH (n=98). A landmark analysis of early (admission to 30 days) and late (31 days to 8 years) mortality and readmission for heart failure was performed. In the first 30 days, RV dysfunction without PH was associated with a high mortality risk (adjusted hazard ratio 5.56, 95% CI 2.05–15.09, P
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