| Autor: |
Alyssa R Martin, Aida Sivro, Zoe R Packman, Eshan U Patel, Livia R Goes, Lyle R McKinnon, Jacquie Astemborski, Gregory D Kirk, Shruti H Mehta, Claudia Cicala, James Arthos, Andrew D Redd, Thomas C Quinn |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 15, Iss 8, p e0238234 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0238234 |
| Popis: |
IntroductionWe performed a cross-sectional study of HIV-uninfected men and women who inject drugs from the ALIVE cohort to examine if black men and women who inject drugs have higher levels of CD4+ T cells expressing the integrin heterodimer α4β7 compared to white men and women.Materials and methodsFlow cytometry was used to examine expression of α4β7 and other markers associated with different functional CD4+ T cell subsets in both men and women who inject drugs.ResultsHigher levels of α4β7, CCR5, and CCR6 were observed on CD4+ T cells from black participants compared with white participants. In a multivariable model, α4β7 expression differed by race, but not sex, age, or other factors.DiscussionBlack men and women express higher percentages of α4β7 expressing CD4+ T cells, which may play a role in HIV disease. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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