Efek asupan vitamin D terhadap tekanan darah sistolik tikus putih (Rattus norvegicus)
| Autor: | Dessy Hermawan, Sri Kadarsih, Sunarti ., Indwiani Astuti, Zaenal Arifin Nang Agus |
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| Jazyk: | indonéština |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Jurnal Gizi Klinik Indonesia, Vol 9, Iss 1, Pp 10-15 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1693-900X 2502-4140 |
| DOI: | 10.22146/ijcn.15363 |
| Popis: | Background: Hypertension still became potential life threatening disease for human life. The prevalence of hypertension was high and tends to increase. Previous study suggested that there was a linier rise in blood pressure at increasing distances from the equator. More recent study indicated that vitamin D insuffi ciency may be associated with elevated blood pressure. Objective: To investigate the effect of vitamin D intake on blood pressure. Method: This was an experimental study with pre-post test group design. The subjects were 20 male Rattus norvegicus aged 8 weeks. Subjects were divided into 5 groups and each groups received treatment as follow: lived in dark cage and consumed vitamin D free diet for 1 – 13 days, then moved to normal cage (dark-light period) and given vitamin D per-oral of 0.25 μg/kg BW for 1 – 5 days. Data of systolic blood pressure was collected and analyzed with paired t test. Results: The absence of vitamin D in diet caused a signifi cant increase in systolic blood pressure (p=0.01) after 7 days of treatment in dark cage. While oral vitamin D supplementation of 0.25 μg/kg BW caused a signifi cant decline of systolic blood pressure since the fi rst day of vitamin D supplementation and the result appeared stronger after 4 days of treatment (p=0.001). Conclusion: Vitamin D intake had a strong infl uence on systolic blood pressure |
| Databáze: | Directory of Open Access Journals |
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