Molecular characterisation of airport malaria : four cases in France during summer 1999
| Autor: | Jafari S., Durand R., Lusina D., Le Bras J. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: | |
| Zdroj: | Parasite, Vol 9, Iss 2, Pp 187-191 (2002) |
| Druh dokumentu: | article |
| ISSN: | 1252-607X 1776-1042 |
| DOI: | 10.1051/parasite/2002092187 |
| Popis: | Four airport malaria cases have been observed in the vicinity of the Roissy-Charles-de-Gaulle International Airport, Paris, France. These cases were geographically very close to each other and clustered in a short period of time during the summer of 1999. The phenotype and genotype of the Plasmodium falciparum isolates obtained from these patients were determined in order to know whether a single mosquito could have infected more than one subject. The genomic characterisation of isolates was performed using the polymorphic markers merozoite surface protein 1 (Mspl) and merozoite surface protein2 (Msp2) genes, the κ and ϖ repeats domains of cg2 and the dihydrofolate reductase (DHFR) genotypes. Results showed identical genotypes for isolates 1, 2 and 4 whereas the genotype of isolate 3 differed at one locus. The molecular analysis was consistent with the hypothesis that all patients could have been bitten by the same mosquito and that patient 3, may have received a different clone and an additional species. In vitro susceptibility data did not confirm or rule out this hypothesis because isolates had the same profile of susceptibility to the tested drugs. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|