| Autor: |
Sirin Cetin, Ayse Ulgen, Pervin Ozlem Balci, Hakan Sivgin, Meryem Cetin, Sevdiye Sivgin, Wentian Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
SciMedicine Journal, Vol 3, Iss 0, Pp 1-9 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2704-9833 |
| DOI: |
10.28991/SciMedJ-2021-03-SI-1 |
| Popis: |
Survival analyses of COVID-19 data has its own unique features, in particular, the existence of two distinct events: death and release from the hospital within a very short period of time. This multiple-event situation belongs to a type where the occurrence of the first event prevents the second event to happen, and vice versa. We carried out two cause-specific univariate Cox regression survival analyses, one for time-to-death and another for time-to-release. Each survival analysis is further split into one for onset of symptom to event time and another for hospitalization to event time. We have also carried out a case-control (death vs. release) analysis without considering the time to event information. We observed that risk factors can be detected by either case-control or survival analysis, even though the goal of the two is quite different. We also observed that the two survival analyses may not both reveal a factor being a risk factor, but only one of them does. We prefer this two rounds of Cox regressions over mixture cure model which is only focused on time-to-death events which usually are sample size limited. By utilizing time-to-release events may greatly increase the sample size needed for revealing risk factors for COVID-19. Doi: 10.28991/SciMedJ-2021-03-SI-1 Full Text: PDF |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
