Prognosis of myocarditis stratified by initial clinical presentation: Does 'intermediate' risk still play a role?

Autor: Daniela Di Lisi, Cristina Madaudo, Maria Gabriella Carmina, Francesco Clemenza, Domenico Scelfo, Eluisa La Franca, Michela Pieri, Giuseppe Vitale, Alfredo Ruggero Galassi, Giuseppina Novo
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: American Heart Journal Plus, Vol 46, Iss , Pp 100458- (2024)
Druh dokumentu: article
ISSN: 2666-6022
DOI: 10.1016/j.ahjo.2024.100458
Popis: Background/aims: Myocarditis is an inflammatory disease with diverse clinical presentations. It is known that low-risk patients have a good prognosis compared to high-risk patients. There are few data regarding the prognosis of intermediate-risk patients. This study aimed to analyze the long-term outcomes of patients with acute myocarditis with different risk profiles at presentation, focusing on the intermediate risk one. Methods: A retrospective multicenter study was conducted, enrolling patients who met the diagnostic criteria for clinically suspected myocarditis with acute presentation. Patients were stratified into high, intermediate and low risk, according to the classification proposed by Sinagra and his team. Cardiovascular adverse events (AEs) were assessed after a median follow-up of 19 months. Echocardiographic and cardiac magnetic resonance (CMR) parameters predictive of adverse events have been reported. Results: We enrolled 127 patients (mean age 30 ± 13 years; 103 men, 24 women). High-risk patients had a higher frequency of adverse events (80 %) compared to other groups (16 %–16 %, p
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