Concurrent and reactivation of hepatitis B virus infection in diffuse large B-cell lymphoma: risk factors and survival outcome

Autor:	Ya-fei Guo, Jing-xin Pan, Wei-huang Zhuang
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Hepatitis B virus Diffuse large B-cell lymphoma Rituximab HBV reactivation Risk factors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Infectious and parasitic diseases RC109-216
Zdroj:	Infectious Agents and Cancer, Vol 13, Iss 1, Pp 1-6 (2018)
Druh dokumentu:	article
ISSN:	1750-9378
DOI:	10.1186/s13027-018-0215-4
Popis:	Abstract Objective To determine the clinical features and survival difference of HBV related and Non-HBV related diffuse large B-cell lymphoma (DLBCL) and to evaluate the occurrence of HBV reactivation in DLBCL patients and related risk factors for HBV reactivation after R-CHOP therapy. Methods A total of 246 patients diagnosed with CD20+ DLBCL were enrolled from June 2010 to June 2015. The medical records and survival data were analysed. Multivariate logistic regression analysis was used to identify predictors of HBV reactivation. Survival curves were performed by the Kaplan–Meier method. Results Among patients enrolled, 80 patients were HBsAg sero-positive and 166 patients were HBsAg sero-negative. Findings showed that HBsAg sero-negative patients were significantly older than that of patients with HBsAg sero-positive (P
Databáze:	Directory of Open Access Journals
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