| Autor: |
Sithembiso Tiyandza Dlamini, Kyaw Moe Htet, Ei Chue Chue Theint, Wei-Ming Li, Hsin-Wen Chang, Hung-Pin Tu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Life, Vol 12, Iss 11, p 1881 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2075-1729 |
| DOI: |
10.3390/life12111881 |
| Popis: |
We investigated the role of vitamin D in the risk of tuberculosis (TB) among patients with end-stage kidney disease (ESKD). The retrospective cohort was conducted with data of 20,985 patients with kidney disease and 20,985 controls without kidney disease (1:1 matching on age of cohort entry and sex) in the duration of 1997–2010 from the Taiwan National Health insurance database. Then, by a case–cohort study, among 20,985 kidney disease, 3194 ESKD patients were identified with matched 3194 non-ESKD patients. Multivariate analyses revealed a significant association between kidney disease and tuberculosis (adjusted incidence rate ratio (IRR) 1.57 (1.33–1.86)), and the risk increased after 3 years of follow-up the (adjusted IRR 3.79 (2.55–5.62)), but after more years of follow-up no significance was observed. We also found that ESKD increases the risk of tuberculosis (adjusted IRR 3.67 (2.27–5.93)). However, vitamin D usage was not related with the tuberculosis risk in ESKD patients (p > 0.1783). Our study showed increased risk of tuberculosis in kidney disease and ESKD patients, and vitamin D was not beneficial in ESKD. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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