| Autor: |
Andrezza Kyunmi Kim, Robyn M Brown, Andrew J. eLawrence |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Frontiers in Behavioral Neuroscience, Vol 6 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1662-5153 |
| DOI: |
10.3389/fnbeh.2012.00078 |
| Popis: |
Orexins (hypocretins) are neuropeptides synthesized in neurons located in the lateral, perifornical and dorsomedial hypothalamus. These neurons innervate many regions in the brain and modulate multiple other neurotransmitter systems. As a result of these extensive projections and interactions orexins are involved in numerous functions, such as feeding behavior, neuroendocrine regulation, the sleep-wake cycle and reward-seeking. This review will summarise the literature to date which has evaluated a role of orexins in the behavioral effects of alcohol, with a focus on understanding the importance of this peptide and its potential as a potential therapeutic target for alcohol use disorders. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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