Chemical carcinogens: implications for cancer treatment

Autor: Shaofeng Liu, Mary Saunders, Tak W. Mak
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
Druh dokumentu: article
ISSN: 1558-8238
DOI: 10.1172/JCI174319
Popis: Carcinogen exposure has been associated with enhanced cancer immunogenicity that is often attributed to neoantigen generation. However, the broader, neoantigen-independent impact of carcinogens on immune responses to cancer cells remains underexplored. In this issue of the JCI, Huang et al. uncover a mechanism wherein carcinogen-treated cancer cells exhibit an inability to establish an immunosuppressive tumor microenvironment (TME) due to reduced M-CSF expression. Intriguingly, the so-called carcinogen-induced tumor-associated macrophages (TAMs) within this TME exhibited anti-tumor properties instead of the conventional immunosuppressive phenotype. This phenomenon extended to human lung cancers, as evidenced by TAM reprogramming in smokers versus nonsmokers. This study substantially advances our understanding of carcinogen-mediated effects on cancer immunogenicity, potentially redirecting approaches to cancer immunotherapy.
Databáze: Directory of Open Access Journals